BDBM50537598 CHEMBL4646628::US11149020, Compound 1 (MW-181)

SMILES CN(C)c1cc(-c2ccncc2)c(nn1)-c1cccc2ccccc12

InChI Key InChIKey=GEAPHVHHVPDTKQ-UHFFFAOYSA-N

Data  3 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50537598   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataKi:  180nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataKi:  184nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataKi:  320nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataIC50:  410nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataIC50: >1.00E+4nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataIC50:  215nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537598(CHEMBL4646628 | US11149020, Compound 1 (MW-181))
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against HIV-1 wild-type reverse transcriptase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB