BDBM50538549 CHEMBL4641424

SMILES Nc1cc(ccn1)-c1cc(Cl)cc2CC(Oc12)C(=O)N1CCNCC1

InChI Key InChIKey=JGHCITCCEQEXTL-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50538549   

TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 47(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of USP47 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of His6-tagged human USP1 expressed in insect Sf21 cells coexpressing untagged UAF1 assessed as cleavage of Ubiquitin-Rhodamine110-glycine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed