BDBM50538677 CHEMBL4635634
SMILES OC(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CN(C)c1ccc(\C=C\C=C\c2cc(C)[n+](CCCCc3c[nH]cn3)c(C)c2)cc1
InChI Key InChIKey=DTAWKPVZONNKTJ-UHFFFAOYSA-M
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50538677
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 3.55E+3nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human recombinant H2R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: <4.79E+3nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS4More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Antagonist activity at mouse H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced beta-...More data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 18nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 31.2nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataKd: 39nMAssay Description:Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryMore data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Binding affinity to recombinant human N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryMore data for this Ligand-Target Pair
Affinity DataKd: 52nMAssay Description:Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryMore data for this Ligand-Target Pair
Affinity DataKd: 52.2nMAssay Description:Binding affinity to recombinant mouse N- terminal NLuc-tagged H4R expressed in HEK293T cells by flow cytometryMore data for this Ligand-Target Pair
Affinity DataKd: 61nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 66nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.5nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataKd: 2.54nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataKd: 9.20nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataKd: 9.16nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataKd: 31nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells assessed as dissociation constant measured after 30 mins in pres...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inverse agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskol...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inverse agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as inhibition of histamine-induced ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inverse agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells assessed as reduction in histamine-induced inhibition of forskol...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at human H3R expressed in HEK293T-SP-FLAG-hH3R-CRE-CBR cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.35nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair