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Target
Histamine H4 receptor
Ligand
BDBM50538677
Substrate
n/a
Meas. Tech.
ChEMBL_1973765 (CHEMBL4606583)
Kd
61±n/a nM
Citation
 Bartole, E; Grätz, L; Littmann, T; Wifling, D; Seibel, U; Buschauer, A; Bernhardt, G UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H J Med Chem 63:5297-5311 (2020) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_MOUSE | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44272.75
Organism:
Mus musculus (mouse)
Description:
Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
  
Inhibitor
Name:
BDBM50538677
Synonyms:
CHEMBL4635634
Type:
Small organic molecule
Emp. Form.:
C30H34F6N4O4
Mol. Mass.:
628.6058
SMILES:
OC(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CN(C)c1ccc(\C=C\C=C\c2cc(C)[n+](CCCCc3c[nH]cn3)c(C)c2)cc1
Structure:
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