BDBM50539899 CHEMBL4640028

SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(nc2c(nccc12)-c1ccn[nH]1)N1CCOCC1

InChI Key InChIKey=FAZDIAPBCWLARY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50539899   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50539899(CHEMBL4640028)
Affinity DataIC50:  59nMAssay Description:Inhibition of 5'-TAMRA-labeled tracer 3',6'-bis(dimethylamino)-N-(4-{[2(1H-indol-4-yl)-6-(morpholin-4-yl)-pyrimidin-4-yl]amino}butyl)-3-oxo-3H-spiro[...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50539899(CHEMBL4640028)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of recombinant human ERG stably expressed in HEK293 cells at -80 mV by whole cell voltage clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50539899(CHEMBL4640028)
Affinity DataIC50:  380nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in histone H2AX phosphorylation measured after 30 mins by immunofluorescence cytometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed