BDBM50540741 CHEMBL4640019

SMILES OCc1cncc(c1)-c1ccc2[nH]nc(C(=O)NCC3CCOCC3)c2c1

InChI Key InChIKey=HMUYSTSHIXJVRO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50540741   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged GSK3beta (1 to 420 end residues) expressed in baculovirus expression system using u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) transfected in HEK cells co-transfected with tau assessed as reduction in tau phosphorylation incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50: <10nMAssay Description:Inhibition of human recombinant GSK3alpha using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate incubated for 60 mins in presence of ATP at Km concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50:  27nMAssay Description:Inhibition of human CDK2/cyclinA using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate incubated for 30 mins in presence of ATP by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50: <10nMAssay Description:Inhibition of human LynB using His-tagged Rb truncated protein as substrate incubated for 30 mins in presence of ATP at Km concentration by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50:  11nMAssay Description:Inhibition of human GRK2 in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CLK1 in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)
Affinity DataIC50: <10nMAssay Description:Inhibition of human DYRK1A in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed