BDBM50541586 CHEMBL4638245

SMILES COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@H](N3CCC(=CC3=O)c3c(F)ccc(Cl)c3F)c3cc-2ccn3)c1

InChI Key InChIKey=AXXYATYQRMPQSN-QUGAMOGWSA-N

Data  15 KI

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50541586   

TargetCoagulation factor XI(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human factor11a using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to human coagulation factor 11a using L-Pyroglutamyl-L-prolyl-L-arginine p-Nitroaniline as substrate assessed as inhibition constant...More data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human activated protein C using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  20nMAssay Description:Inhibition of human chymotrypsin by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human factor-12a using H-(D)-CHT-Gly-ArgpNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human factor-7a using H-(D)-Ile-Pro-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  4.10E+3nMAssay Description:Inhibition of human tissue-type plasminogen activator using methyl-sulfonyl-D-cyclohexylalanyl-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of human plasma kallikrein using H-(D)-Pro-Phe-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition of human factor-10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human thrombin using pyro-Glu-Pro-Arg-pNA(para-nitroaniline substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human tissue-type plasminogen activator using H-(D)-Val-Leu-Lys-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human urokinase using pyro-Glu-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >2.10E+4nMAssay Description:Inhibition of human plasmin using H-(D)-Val-Leu-Lys-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >2.70E+4nMAssay Description:Inhibition of human factor-9a using Methyl-sulfonyl-D-cyclohexylglycyl-Gly-Arg-AMC substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human tissue kallikrein-1 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed