BDBM50541586 CHEMBL4638245
SMILES COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@H](N3CCC(=CC3=O)c3c(F)ccc(Cl)c3F)c3cc-2ccn3)c1
InChI Key InChIKey=AXXYATYQRMPQSN-QUGAMOGWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50541586
Affinity DataKi: 0.260nMAssay Description:Inhibition of human factor11a using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Binding affinity to human coagulation factor 11a using L-Pyroglutamyl-L-prolyl-L-arginine p-Nitroaniline as substrate assessed as inhibition constant...More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of human activated protein C using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human chymotrypsin by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of human factor-12a using H-(D)-CHT-Gly-ArgpNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of human factor-7a using H-(D)-Ile-Pro-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMAssay Description:Inhibition of human tissue-type plasminogen activator using methyl-sulfonyl-D-cyclohexylalanyl-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of human plasma kallikrein using H-(D)-Pro-Phe-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >9.00E+3nMAssay Description:Inhibition of human factor-10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human thrombin using pyro-Glu-Pro-Arg-pNA(para-nitroaniline substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human tissue-type plasminogen activator using H-(D)-Val-Leu-Lys-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol Myers Squibb
Curated by ChEMBL
Bristol Myers Squibb
Curated by ChEMBL
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human urokinase using pyro-Glu-Gly-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >2.10E+4nMAssay Description:Inhibition of human plasmin using H-(D)-Val-Leu-Lys-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >2.70E+4nMAssay Description:Inhibition of human factor-9a using Methyl-sulfonyl-D-cyclohexylglycyl-Gly-Arg-AMC substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human tissue kallikrein-1 by spectrophotometryMore data for this Ligand-Target Pair