BDBM50542086 CHEMBL4649161

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OC2CN(CCCF)C2)cc1F

InChI Key InChIKey=BKHIBYHLBQEIQK-XGCWNURASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542086   

TargetEstrogen receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161)
Affinity DataIC50:  0.0530nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161)
Affinity DataIC50:  0.140nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161)
Affinity DataIC50:  0.0310nMAssay Description:Induction of ERalpha degradation in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed