BDBM50542225 CHEMBL4643684

SMILES CC(C)N(C(=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NO

InChI Key InChIKey=CLEDVPXGVTYVTP-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50542225   

TargetHistone deacetylase 3(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of C-terminal His-tagged and N-terminal GST-tagged full length human HDAC3 expressed in baculovirus expression system co-expressed with hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human HDAC6 expressed in baculovirus expression system using FAM-RHKK(Ac)-NH2 substrate incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataIC50:  63nMAssay Description:Binding affinity to human HDAC8 pre-incubated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC11 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataKd:  7.70nMAssay Description:Binding affinity to His-tagged recombinant human HDAC8 by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542225(CHEMBL4643684)
Affinity DataIC50:  65nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC8 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed