BDBM50543586 CHEMBL4644441

SMILES Cl.CCNC(=O)c1ccc(cn1)-c1c(C)nc2c(OCc3ccc(cc3)-c3ccc(F)cc3)cccn12

InChI Key InChIKey=DOPRKNQCKUHFSE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50543586   

TargetPresenilin-1(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543586(CHEMBL4644441)
Affinity DataIC50:  75nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed