BDBM50544831 CHEMBL4634979

SMILES COc1cc(ccc1OCCCN1CCOCC1)-c1cnc2cccc(-c3cc(F)c(CN4CCS(=O)(=O)CC4)c(F)c3)c2n1

InChI Key InChIKey=NVOIBHOEZNKMBT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50544831   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544831(CHEMBL4634979)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544831(CHEMBL4634979)
Affinity DataIC50:  316nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC cells assessed as reduction in IL2-induced IFNgamma productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544831(CHEMBL4634979)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50544831(CHEMBL4634979)
Affinity DataIC50:  0.251nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed