BDBM50546132 CHEMBL4759048

SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1

InChI Key InChIKey=KEEHEUGOPCFXAV-VXKWHMMOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546132   

TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  9nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  150nMAssay Description:Inhibition of SPPL2a in Balb/c mouse A20 cells assessed as reduction in CD74/p8 NTF accumulation incubated for overnight by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2B(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  270nMAssay Description:Inhibition of SPPL2b in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  4nMAssay Description:Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse SPPL2a cotransfected with EGFP-NLP-fused TNFalpha (1 to 77 residues)-NTF incubated for 24 hrs by Hoechst staining based Cellomics...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed