BDBM50547378 CHEMBL4754421

SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCCC(O)=O)c1ccccc1Cl)-c1ccccc1

InChI Key InChIKey=ZIDVHLLOHYVUEZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50547378   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50547378(CHEMBL4754421)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50547378(CHEMBL4754421)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50547378(CHEMBL4754421)
Affinity DataIC50:  5.20nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50547378(CHEMBL4754421)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50547378(CHEMBL4754421)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed