BDBM50547397 LU-31-130::Lu 31-130::Zicronapine

SMILES CN1CCN(CC1(C)C)[C@@H]1C[C@H](c2ccc(Cl)cc12)c1ccccc1

InChI Key InChIKey=BYPMJBXPNZMNQD-PZJWPPBQSA-N

Data  22 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50547397   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma.

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.130nMAssay Description:Binding affinity to human dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma.

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT6 receptor measured after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  0.960nMAssay Description:Displacement of [125I](+/-)DOI from recombinant human 5-HT2A receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I](+/-)DOI from recombinant human 5-HT2C receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1B receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1A receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]pyrilamine from recombinant human H1 receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]7-OH-DPAT from recombinant human D2S receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D4.4 receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]RX 821002 from recombinant human alpha2C receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(3) dopamine receptor(Homo sapiens)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  28nMAssay Description:Binding affinity to human dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]RX 821002 from recombinant human alpha2B receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]CYP from rat brain 5HT1B receptor measured after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]RX 821002 from recombinant human alpha2A receptor measured after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50547397(LU-31-130 | Lu 31-130 | Zicronapine)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human DAT measured after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed