BDBM50547986 CHEMBL4786638

SMILES N[C@H]1CC[C@@H](CC1)Nc1ncnc2c(csc12)C(=O)Nc1c(Cl)ccc(NS(=O)(=O)c2cc(F)ccc2F)c1F

InChI Key InChIKey=NALUYXQOXMHJMM-HDJSIYSDSA-N

Data  1 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50547986   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Paraza Pharma

Curated by ChEMBL
LigandPNGBDBM50547986(CHEMBL4786638)
Affinity DataKi:  1.40nMAssay Description:Inhibition of of human recombinant His6-tagged B-Raf V600E mutant expressed in baculovirus infected cells co-expresing CDC37 in presence of [gamma33P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma

Curated by ChEMBL
LigandPNGBDBM50547986(CHEMBL4786638)
Affinity DataIC50:  24nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Paraza Pharma

Curated by ChEMBL
LigandPNGBDBM50547986(CHEMBL4786638)
Affinity DataIC50:  320nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB