BDBM50548111 CHEMBL4763327

SMILES CNc1nc(OCCOC)nc2n(Cc3ccccc3)c(=O)[nH]c12

InChI Key InChIKey=OSILWVXKFRDCIL-UHFFFAOYSA-N

Data  1 IC50  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548111   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548111(CHEMBL4763327)
Affinity DataEC50:  1.50E+3nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548111(CHEMBL4763327)
Affinity DataIC50:  536nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetToll-like receptor 7(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548111(CHEMBL4763327)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548111(CHEMBL4763327)
Affinity DataKd:  440nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB