BDBM50550659 CHEMBL4763108
SMILES [H][C@@]12CN(CCOc3ccc4Sc5c(Cc4c3)cccc5-c3cc(=O)cc(o3)N3CCOCC3)[C@@]([H])(CO1)C2
InChI Key InChIKey=FMAIGHDZPIKVKX-ZJSXRUAMSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50550659
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair