BDBM50552555 CHEMBL4783398
SMILES Cc1ccc(c(c1)[N+]([O-])=O)-n1cc(COc2cccc3cnc(Nc4cccc(Cl)c4)nc23)nn1
InChI Key InChIKey=JEPGNFQKCRZPHJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50552555
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human CLK1 (130 to end residues) using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma33P-ATP] by...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of recombinant human full length CLK3 using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma33P-ATP] by scintilla...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human CLK4 (128 to end residues) using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate incubated for 40 mins in presence of [gam...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of rat DYRK1A (1 to 499 residues) assessed as residual activity by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Chemveda Life Sciences India
Curated by ChEMBL
Chemveda Life Sciences India
Curated by ChEMBL
Affinity DataKd: 112nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human CLK2 (138 to end residues) using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate incubated for 40 mins in presence of [gam...More data for this Ligand-Target Pair