BDBM50555347 CHEMBL4758009::US11306078, Example 2.09

SMILES CC1(CN2CC[C@H](NC(=O)c3cc(on3)-c3ccc(F)cc3F)[C@H](C2)C(=O)NC2(CC2)c2ncccn2)CC1

InChI Key InChIKey=DVJLXIAHLNHSGM-FPOVZHCZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50555347   

TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555347(CHEMBL4758009 | US11306078, Example 2.09)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555347(CHEMBL4758009 | US11306078, Example 2.09)
Affinity DataIC50:  3nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555347(CHEMBL4758009 | US11306078, Example 2.09)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed