BDBM50555755 CHEMBL4786020
SMILES FC(F)(F)c1cc2Nc3nc(NCCC\C=C/COc(c2)c1)nc(n3)-c1cccc(n1)C(F)(F)F
InChI Key InChIKey=FAMLELDKQOPNEV-RQOWECAXSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50555755
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Hangzhou Institute Of Innovative Medicine
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair