BDBM50557456 CHEMBL4753306::US11401270, Example 61
SMILES CNCC[C@H](Oc1cccc(c1)N1CCN(C)CCC1=O)c1cccs1
InChI Key InChIKey=SOZQYEAKFLBWCU-SFHVURJKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50557456
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 382nMAssay Description:Displacement of [3H]-nisoxetine from human NET expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 1.75E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 1.75E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 2.80E+3nMAssay Description:Displacement of [3H]-gabapentin from human Cav alpha2delta1 expressed in CHO-K1 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataIC50: 97nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as reduction in ASP+ uptake incubated for 20 mins before ASP+ addition and measured after ...More data for this Ligand-Target Pair