BDBM50560174 GSK789
SMILES CN1CC[C@@H](Nc2ncc(-c3ccco3)c3cc(C)c(=O)[nH]c23)[C@@H](C1)C(=O)NC1CCCCC1
InChI Key InChIKey=NDEORODKVUYMFQ-NHCUHLMSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50560174
Affinity DataKd: <2.51E+4nMAssay Description:Binding affinity to full length BRD2 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of AlexaFluor 488-labelled BD-AF488 from TAF1 BD2 (unknown origin) incubated for 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
TargetBromodomain adjacent to zinc finger domain protein 2A(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 1.58E+4nMAssay Description:Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2B(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 1.58E+4nMAssay Description:Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-thr-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant (unknown origin) after 30 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+4nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant (unknown origin) after 30 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataKd: 20nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 1 long isoform (K71 to N194 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 1 (P24 to E144 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 20nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
Affinity DataKd: 20nMAssay Description:Binding affinity to human partial length BRDT bromodomain 1 (N21 to E137 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.51E+4nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan a...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 2 (G306 to P416 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.16E+4nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 2 long isoform (K333 to E460 residues) expressed in bacterial expression system by BROMOsca...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to human partial length BRDT bromodomain 2 (K250 to E382 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 1.58E+4nMAssay Description:Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Binding affinity to full length BRD2 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Binding affinity to full length BRD3 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 6.30nMAssay Description:Binding affinity to full length BRD4 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to full length BRDT BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
Affinity DataKd: <2.00E+4nMAssay Description:Binding affinity to full length BRD4 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
Affinity DataKd: <3.16E+4nMAssay Description:Binding affinity to full length BRDT BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1-like(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 398nMAssay Description:Binding affinity to human partial length TAF1L bromodomain 2 (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Binding affinity to full length TAF1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoproteomi...More data for this Ligand-Target Pair
Affinity DataKd: 6.31E+3nMAssay Description:Binding affinity to full length BRD3 BD2 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair