BDBM50563276 CHEMBL4751615
SMILES CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1
InChI Key InChIKey=QTCSXAUJBQZZSN-UHFFFAOYSA-N
Data 23 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50563276
Affinity DataIC50: 354nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC class 1 in human THP-1 cells using TFA-lysine as fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC class 1 in human PANC-1 cells using TFA-lysine as fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC class 1 in human L3.6pl cells using TFA-lysine as fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC class 1 in human HT-29 cells using TFA-lysine as fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC class 1 in human HT-29 cells using Boc-Lys-Ac as substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant human HDAC5 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant human HDAC7 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC10 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC11 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC1 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC2 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC3 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human HDAC6 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair