BDBM50565051 CHEMBL4783930
SMILES COc1ccc(cc1)-c1cc(OC(C)=O)c2c(c(NC(=O)c3ccccc3C)oc2c1)-c1cccs1
InChI Key InChIKey=KFIFBXUHWWIHKN-UHFFFAOYSA-N
Data 24 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50565051
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 0.880nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 397nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured aft...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincris...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincris...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitax...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitax...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 525nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorub...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 478nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorub...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measur...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 345nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measur...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured a...More data for this Ligand-Target Pair