BDBM50565052 CHEMBL4792609
SMILES COc1ccc(cc1)-c1cc(OC(C)=O)c2c(c(NC(=O)c3ccccc3Cl)oc2c1)-c1cccs1
InChI Key InChIKey=NVHVRYUFNCFLGC-UHFFFAOYSA-N
Data 24 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50565052
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 0.880nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured aft...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 114nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincris...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincris...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 602nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitax...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitax...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 564nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorub...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 502nMAssay Description:Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorub...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 111nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measu...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5 uM measure...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measur...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measur...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
China Medical University
Curated by ChEMBL
China Medical University
Curated by ChEMBL
Affinity DataIC50: 0.820nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured a...More data for this Ligand-Target Pair