BDBM50567169 CHEMBL4873876

SMILES CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(Cl)cn3)o2)c(O)c1-c1c(OC)cccc1OC

InChI Key InChIKey=AGZKELPIAJYRDT-UHFFFAOYSA-N

Data  1 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50567169   

TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataKi:  0.0740nMAssay Description:Displacement of [3H]Apelin-13 from human APJ receptor stably expressed in human HEK293 cell membrane incubated for 120 mins by TopCount scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0240nMAssay Description:Agonist activity at rat APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0230nMAssay Description:Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rattus norvegicus)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0240nMAssay Description:Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  0.0230nMAssay Description:Agonist activity at human APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50567169(CHEMBL4873876)
Affinity DataEC50:  7.10nMAssay Description:Agonist activity at human APJ receptor stably expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed