BDBM5057 1,2,4-Oxadiazole Analogue 4b::4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(4-methylphenyl)methyl]-1,2,4-oxadiazol-5-yl}propyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid

SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(C)cc2)no1

InChI Key InChIKey=KRWYKNGWCCKFER-SFTDATJTSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5057   

TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5057(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  6.50E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5057(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50: >5.00E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5057(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  2.92E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed