BDBM50571557 CHEMBL4853072
SMILES COc1ccc(CCc2nc3cc(ccn3c2NC2CCCCC2)-c2c(C)noc2C)cc1Cl
InChI Key InChIKey=NZXSWCLCRDCHGN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50571557
Affinity DataIC50: 72nMAssay Description:Inhibition of His-tagged CBP (unknown origin) using biotinylated-H3K56ac peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Massachusetts Boston
Curated by ChEMBL
University Of Massachusetts Boston
Curated by ChEMBL
Affinity DataIC50: 5.19E+3nMAssay Description:Inhibition of His-tagged BRD4 BD1 (unknown origin) using biotinylated-JQ1 peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Massachusetts Boston
Curated by ChEMBL
University Of Massachusetts Boston
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BromoELEC...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Massachusetts Boston
Curated by ChEMBL
University Of Massachusetts Boston
Curated by ChEMBL
Affinity DataKd: 215nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair
Affinity DataKd: 315nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair