BDBM50571557 CHEMBL4853072

SMILES COc1ccc(CCc2nc3cc(ccn3c2NC2CCCCC2)-c2c(C)noc2C)cc1Cl

InChI Key InChIKey=NZXSWCLCRDCHGN-UHFFFAOYSA-N

Data  2 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50571557   

TargetCREB-binding protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571557(CHEMBL4853072)
Affinity DataIC50:  72nMAssay Description:Inhibition of His-tagged CBP (unknown origin) using biotinylated-H3K56ac peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571557(CHEMBL4853072)
Affinity DataIC50:  5.19E+3nMAssay Description:Inhibition of His-tagged BRD4 BD1 (unknown origin) using biotinylated-JQ1 peptide as substrate incubated for 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571557(CHEMBL4853072)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BromoELEC...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571557(CHEMBL4853072)
Affinity DataKd:  215nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50571557(CHEMBL4853072)
Affinity DataKd:  315nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BromoELECT assayMore data for this Ligand-Target Pair