BDBM50573471 CHEMBL4856360
SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
InChI Key InChIKey=ISZRWOBBNIOIMU-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50573471
Affinity DataIC50: 2nMAssay Description:Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...More data for this Ligand-Target Pair