BDBM50575350 CHEMBL4877264

SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12

InChI Key InChIKey=YFVCYTODGMGPAD-IYBDPMFKSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50575350   

TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  44nMAssay Description:Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  840nMAssay Description:Inhibition of Tel fused KDR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by manual patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  46nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  1.90E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in CHO cell after 90 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of RET (658 to 1072) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB