BDBM50575351 CHEMBL4874648

SMILES COC(=O)N[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12

InChI Key InChIKey=UYXYKLOTLJDLNL-BETUJISGSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50575351   

TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50:  15nMAssay Description:Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50:  660nMAssay Description:Inhibition of Tel fused KDR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by manual patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50:  2.50E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in CHO cell after 90 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50:  35nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed