BDBM50575352 CHEMBL4857808
SMILES COC(=O)NC12CCC(CC1)(CC2)n1cc(-c2ccc(Cl)c(N)c2)c2c(N)ncnc12
InChI Key InChIKey=NWKUBTQEYKTRNT-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50575352
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hr...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of Tel fused KDR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell p...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by manual patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 9.90E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in CHO cell after 90 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair