BDBM50580117 CHEMBL5076176

SMILES Cn1c(Nc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2n(C)c(=O)n(Cc3cc4c(Cl)cccc4[nH]3)c(=O)c12

InChI Key InChIKey=LGCVZTAPKMDJBU-FQEVSTJZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50580117   

TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50580117(CHEMBL5076176)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50580117(CHEMBL5076176)
Affinity DataIC50:  190nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD2 (36 to 350 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed