BDBM50580530 CHEMBL5092744

SMILES OC[C@@H](NCc1cc(Cl)c(OCc2cccc(c2Br)-c2ccccc2)cc1OCc1ccc2nonc2c1)C(O)=O

InChI Key InChIKey=OUHGBSZZOWVTDI-AREMUKBSSA-N

Data  2 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50580530   

TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human PD-1/PD-L1 interaction assessed as blockade activity incubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human PD-L1 assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death protein 1(Homo sapiens)TBA
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataKd:  3.30nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50580530(CHEMBL5092744)
Affinity DataEC50:  375nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in human Jurkat cells expressing PD-1/NFAT/Luc cocultured with CHO-K1 cells expressing PD-L1/aAPC assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed