BDBM50581135 CHEMBL3701715

SMILES Cl.[H][C@@]12CN(C[C@@]1(N=C(N)SC2)c1ccc(s1)C#N)c1ncc(F)cn1

InChI Key InChIKey=CEMKBBMCDHHRMT-UXZWUECBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581135   

TargetBeta-secretase 1(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581135(CHEMBL3701715)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Mus musculus (Mouse))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581135(CHEMBL3701715)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581135(CHEMBL3701715)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human Cathepsin D by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed