BDBM50582709 CHEMBL5078779
SMILES C[C@@H]1CCCN1c1[nH]c2ncnc(N)c2c1C#N
InChI Key InChIKey=FWMJSDVHISWSPV-SSDOTTSWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50582709
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)
Curated by ChEMBL
Vernalis (R&D)
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity to human LRRK2 WT incubated for 2 hrs by TR-FRET based Lanthascreen kinase activity assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)
Curated by ChEMBL
Vernalis (R&D)
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Binding affinity to human GST tagged truncated LRRK2 G2019S mutant incubated for 2 hrs by TR-FRET based Lanthascreen kinase activity assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)
Curated by ChEMBL
Vernalis (R&D)
Curated by ChEMBL
Affinity DataIC50: 166nMAssay Description:Inhibition of recombinant human LRRK2 WT using fluorescein-labeled LRRKtide as substrate in presence of ATP preincubated for 50 mins followed by anti...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)
Curated by ChEMBL
Vernalis (R&D)
Curated by ChEMBL
Affinity DataIC50: 201nMAssay Description:Inhibition of recombinant human GST tagged truncated LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate in presence of ATP preincuba...More data for this Ligand-Target Pair