BDBM50583520 CHEMBL5094006

SMILES CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)nc-21

InChI Key InChIKey=QMTKZAHTDPRIFJ-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50583520   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataKi:  0.830nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataKi:  14.2nMAssay Description:Covalent inhibition of human full length N-terminal GST-fused MPS1 (1 to 857 residues) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK2 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 3(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK3 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-2(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human recombinant P70S6Kbeta expressed in Sf9 insect cells using [KKRNRTLTK] as substrate in presence of [33P]-ATP by radiometric hotsp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured immediately in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 1 hr in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 2 hrs in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate measured after 4 hrs in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Sf9 insect cells using poly[Glu:Tyr] 4:1 as substrate in presence of [33P]-ATP by radiometric hots...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  22nMAssay Description:Displacement of tracer K9 from NanoLuc-fused MPS1 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eberhard Karls University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human full length N-terminal GST-fused MPS1 (1 to 857 residues) using histone H3 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed