BDBM50586355 CHEMBL5087243

SMILES OP(O)(=O)Oc1cc(cc(OP(O)(O)=O)c1OP(O)(O)=O)-c1cc(OP(O)(O)=O)c(OP(O)(O)=O)c(OP(O)(O)=O)c1

InChI Key InChIKey=XJTGIQJLTGTMQT-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50586355   

TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586355(CHEMBL5087243)
Affinity DataIC50:  23nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586355(CHEMBL5087243)
Affinity DataIC50:  700nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586355(CHEMBL5087243)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed