BDBM50586944 CHEMBL5090821

SMILES CS(=O)(=O)Nc1ccc(CNC(=O)c2ccc3n(Cc4cccc(F)c4)ccc3c2)c(c1)C(F)(F)F

InChI Key InChIKey=WWVQEDHOKLQQAY-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50586944   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586944(CHEMBL5090821)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586944(CHEMBL5090821)
Affinity DataIC50:  1.62E+3nMAssay Description:Partial agonist activity at recombinant sGSF-PPARgamma (unknown origin) assessed as reduction in rosiglitazone induced CBP-1 recruitment incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586944(CHEMBL5090821)
Affinity DataIC50:  46nMAssay Description:Inhibition of N-terminal His-tagged mouse sEH (2 to 554 residues) expressed in Escherichia coli Rosetta2 (DE3) assessed as reduction in 6-methoxy-2-n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed