BDBM505890 8-chloro-6-(((S)-(1-(1-(difluoromethyl)- cyclopropyl)-1H-1,2,3-triazol-4-yl)(6- fluoro-2-methylpyridin-3-yl)methyl)- amino)-4-(((R)-3,3-dimethyltetrahydro- 2H-pyran-4-yl)amino)quinoline-3- carbonitrile::US11066414, Compound 539

SMILES Cc1nc(F)ccc1[C@H](Nc1cc(Cl)c2ncc(C#N)c(N[C@@H]3CCOCC3(C)C)c2c1)C1=CN(NN1)C1(CC1)C(F)F

InChI Key InChIKey=LNRBUAXDZPRBES-KCWPFWIISA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 505890   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM505890(8-chloro-6-(((S)-(1-(1-(difluoromethyl)- cycloprop...)
Affinity DataIC50:  1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent