BDBM50589186 CHEMBL5189379
SMILES CN1CCN(CC1)C(C)(C)\C=C(/C#N)C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12
InChI Key InChIKey=NNGVMERLTTVLQP-UKPAFZAXSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50589186
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of biotinylated-labeled BTK-selective probe binding to BTK in human Ramos assessed as target occupancy pretreated for 1 hr followed by pro...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 980nMAssay Description:Inhibition of EGFR (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of RLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of ERBB4 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of ITK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Principia Biopharma, A Sanofi
Curated by ChEMBL
Principia Biopharma, A Sanofi
Curated by ChEMBL
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of ERBB2 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair