BDBM50591066 CHEMBL5190023
SMILES CNC(=O)[C@]1(C)CC[C@H](C1)Nc1ncc2c(Br)nn(-c3ccc(cc3)-c3nnc(C)s3)c2n1
InChI Key InChIKey=ASGMFNBUXDJWJJ-JLCFBVMHSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50591066
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Rapt Therapeutics
Curated by ChEMBL
Rapt Therapeutics
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HRI (unknown origin)More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Rapt Therapeutics
Curated by ChEMBL
Rapt Therapeutics
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Rapt Therapeutics
Curated by ChEMBL
Rapt Therapeutics
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha in presence of human serum by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:Inhibition of CDKL2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 143nMAssay Description:Inhibition of CDKL3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 118nMAssay Description:Inhibition of CDKL4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetTranscription initiation factor TFIID subunit 1-like(Homo sapiens (Human))
Rapt Therapeutics
Curated by ChEMBL
Rapt Therapeutics
Curated by ChEMBL
Affinity DataIC50: 124nMAssay Description:Inhibition of TAF1L (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Rapt Therapeutics
Curated by ChEMBL
Rapt Therapeutics
Curated by ChEMBL
Affinity DataIC50: 191nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin)More data for this Ligand-Target Pair