BDBM50591066 CHEMBL5190023

SMILES CNC(=O)[C@]1(C)CC[C@H](C1)Nc1ncc2c(Br)nn(-c3ccc(cc3)-c3nnc(C)s3)c2n1

InChI Key InChIKey=ASGMFNBUXDJWJJ-JLCFBVMHSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50591066   

TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  16nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HRI (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha in presence of human serum by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase-like 2(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  165nMAssay Description:Inhibition of CDKL2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase-like 3(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  143nMAssay Description:Inhibition of CDKL3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase-like 4(Homo sapiens)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  118nMAssay Description:Inhibition of CDKL4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  101nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranscription initiation factor TFIID subunit 1-like(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  124nMAssay Description:Inhibition of TAF1L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591066(CHEMBL5190023)
Affinity DataIC50:  191nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed