BDBM50592745 CHEMBL5188373

SMILES COCC1CN(C1)C1CCN(CC1)c1cc(OC)c(Nc2ncc(Br)c(Nc3ccc4OCCOc4c3P(C)(C)=O)n2)cc1C

InChI Key InChIKey=LVLFSSZNAIKYCD-UHFFFAOYSA-N

Data  30 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50592745   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  0.310nMAssay Description:Inhibition of EGFR del18/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  7.80nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetAurora kinase A(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  455nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  41nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetEphrin type-A receptor 1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  292nMAssay Description:Inhibition of EphA1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetEphrin type-B receptor 2(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  1.30nMAssay Description:Inhibition of FER (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  4.70nMAssay Description:Inhibition of ROS (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  3.40nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK6/cyclin-D3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  183nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  5.65E+3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  11nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  4.66E+3nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetPolycystin-1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  81nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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GoogleScholar

Ligand InfoPC cidPC sid

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TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  357nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  266nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  4.09E+3nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetFocal adhesion kinase 1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  0.510nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  131nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetRho-associated protein kinase 1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  104nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  441nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetEpidermal growth factor receptor(Homo sapiens (Human))
Southeast University

Curated by ChEMBL

LigandBDBM50592745(CHEMBL5188373)Copy SMILESCopy InChI

Affinity DataIC50:  0.0900nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails PubMed
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