BDBM50594439 CHEMBL5178175

SMILES Cc1cnc(Nc2ccc(C(=O)NC3CCN(CC3)C(=O)CCOCCOCCOCCOCCC(=O)N3CCC(CC3)NC(=O)c3ccc(Nc4ncc(C)c(Nc5ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c5)n4)cc3F)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1

InChI Key InChIKey=AMHWRJBEKUEFFO-UHFFFAOYSA-N

Data  6 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50594439   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  6.40nMAssay Description:Inhibition of recombinant human BRD4-1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  3nMAssay Description:Inhibition of recombinant human BRD4-2 (333 to 460 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged BRDT-T (2 to 416 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  0.920nMAssay Description:Inhibition of recombinant human BRDT-1 (21 to 137 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain testis-specific protein(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  1.70nMAssay Description:Inhibition of recombinant human BRDT-2 (250 to 382 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594439(CHEMBL5178175)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to BRD4-T (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB