BDBM50596133 CHEMBL5081193

SMILES Fc1cc(ccn1)-n1ccc(NC(=O)C2(CC2)c2ccccc2F)n1

InChI Key InChIKey=UWMKZOSESQVNAA-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50596133   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  13nMAssay Description:Inhibition of ELOVL1 in human HEK293 cells assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  900nMAssay Description:Inhibition of ELOVL1 (unknown origin) using C22-acyl-CoA as substrate by radiometric enzyme assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 7(Homo sapiens)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of ELOVL7 (unknown origin) using C18-acyl-CoA as substrate by radiometric enzyme assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  13nMAssay Description:Inhibition of ELOVL1 in human HEK2936E cells assessed as reduction of C26:0 LPC synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 4(Homo sapiens)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of ELOVL4 (unknown origin) in presence of C26-acyl-CoA by radiometric enzyme assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  5nMAssay Description:Inhibition of ELOVL1 in Het Female 1 patient-derived human lymphocyte assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  43nMAssay Description:Inhibition of ELOVL1 in AMN 1 patient-derived fibroblast assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  17nMAssay Description:Inhibition of ELOVL1 in AMN 2 patient-derived fibroblast assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  15nMAssay Description:Inhibition of ELOVL1 in CALD patient-derived human lymphocyte assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  11nMAssay Description:Inhibition of ELOVL1 in human microglia assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  9nMAssay Description:Inhibition of ELOVL1 in Het Female 2 patient-derived human lymphocyte assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElongation of very long chain fatty acids protein 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50596133(CHEMBL5081193)
Affinity DataIC50:  20nMAssay Description:Inhibition of ELOVL1 in CALD patient-derived human fibroblast assessed as reduction of C26:0 VLCFA synthesis incubated for 48 hrs by cellular assayMore data for this Ligand-Target Pair
In DepthDetails PubMed