BDBM50597496 CHEMBL5206259

SMILES COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ccncc1F

InChI Key InChIKey=CIPXFTLGPVQJKN-HUUCEWRRSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50597496   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  25nMAssay Description:Inhibition of wild-type human full length LIMK2 (M1 to P638 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  1.10E+3nMAssay Description:Time dependent inhibition of CYP1A2 in pooled human liver microsomes using midazolam as substrate preincubated for 30 mins in presence of NADPH follo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597496(CHEMBL5206259)
Affinity DataIC50:  2.25E+3nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In DepthDetails PubMed