BDBM50600733 CHEMBL5182534
SMILES CC(C)(F)c1nc(no1)C12CCC(CN(C(=O)[C@H]3C[C@@](O)(C3)C(F)(F)F)c3cccc(c3)-c3ccc(cc3)C(C)(C)O)(CC1)CC2
InChI Key InChIKey=AEMZJBZKICOPPC-RNMMDBENSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50600733
TargetBile acid receptor(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 34nMAssay Description:Agonist activity at Gal4-fused human FXR in HEK293 cells incubated for 15 min by luciferase reporter assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Mus musculus)
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at mouse LBD fused FXR in HEK293 cells incubated for 30 min by envision plate reader methodMore data for this Ligand-Target Pair
TargetRNA-binding protein FXR2(Homo sapiens)
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human FXR2 expressed in Huh-7 cells coexpressing BSEP relative to GW2064More data for this Ligand-Target Pair
TargetRNA-binding protein FXR2(Homo sapiens)
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 191nMAssay Description:Agonist activity at human FXR2 expressed in HEK293 cells coexpressing human FGF19 incubated for 24 hrs by ELISA analysisMore data for this Ligand-Target Pair
TargetRNA-binding protein FXR2(Homo sapiens)
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 85nMAssay Description:Agonist activity at human FXR2 expressed in HEK293 cells coexpressing IBABPMore data for this Ligand-Target Pair
TargetRNA-binding protein FXR2(Homo sapiens)
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 389nMAssay Description:Agonist activity at human FXR2 expressed in Huh-7 cells coexpressing BSEPMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 5.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hr...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs by...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs b...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs by...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs by...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using fluorogenic substrate preincubated for 15 min followed by NADPH addition measured after 2 hrs by...More data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Biocon-Bristol Myers Squibb Research And Development Center
Curated by ChEMBL
Affinity DataEC50: 42nMAssay Description:Agonist activity at LBD fused human FXR in HEK293 cells incubated for 30 min by envision plate reader methodMore data for this Ligand-Target Pair