BDBM50601642 CHEMBL5188533

SMILES CCc1cccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cnccn2)B(O)O)c1

InChI Key InChIKey=RQXXOBNVVACHIB-UNMCSNQZSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50601642   

TargetProteasome subunit beta type-9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50:  41nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProteasome subunit beta type-6(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProteasome subunit beta type-7(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human 20S proteasome beta2 subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB