BDBM50604564 CHEMBL5191531

SMILES COC(=O)[C@H](CC(C)C)Nc1nc(Cl)nc(N[C@H]2CC[C@@H](CC2)Nc2nc(Cl)nc(N[C@@H](CC(C)C)C(=O)OC)n2)n1

InChI Key InChIKey=JRJMSGATOBMXAC-XSLAGTTESA-N

Data  2 IC50  1 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50604564   

TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataEC50:  470nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation preincubated with M372049 for 15 mins followed by compound treat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataEC50:  970nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataKd:  9.57E+4nMAssay Description:Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as dissociation constant by surface plasmon resonance analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataEC50:  2.64E+3nMAssay Description:Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataIC50:  4.96E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataIC50:  3.78E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAtrial natriuretic peptide receptor 3(Mus musculus)
University College London

Curated by ChEMBL
LigandPNGBDBM50604564(CHEMBL5191531)
Affinity DataEC50:  1.16E+3nMAssay Description:Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed