BDBM50605511 CHEMBL5193786
SMILES Cn1cc(NC(=O)c2cc(c[nH]2)C(=O)c2c(Cl)ccc(Cl)c2F)cn1
InChI Key InChIKey=LIEUQFMVFKJKHX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50605511
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 1.30nMAssay Description:Binding affinity to wild type human partial length JAK3 (I781 to S1124 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length ERK5 in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by dual lucif...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 141nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 46nMAssay Description:Binding affinity to wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase DCLK1(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 61nMAssay Description:Binding affinity to wild-type human partial length DCLK1 (L270 to A662 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 180nMAssay Description:Binding affinity to wild-type human partial length MAPK7 (M1 to A409 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 220nMAssay Description:Binding affinity to wild-type human partial length LRRK2 (H970 to E2527 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding affinity to wild-type human partial length AURKA (E122 to K401 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 380nMAssay Description:Binding affinity to wild-type human partial length FGFR1 (P357 to V669 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 420nMAssay Description:Binding affinity to human partial length KIT (I571 to D952 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 1.20nMAssay Description:Binding affinity to human partial length ABL1 by Kinomescan assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataKd: 2.80nMAssay Description:Binding affinity to wild type human partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of ERK5 (1 to 492 residues) in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by du...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair